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Z., Corke, H., Wang, D., & Li, W

Supporting cellular anti-inflammatory pathways through magnesium, vitamin C, vitamin D, and omega-3 supplementation may help reduce inflammatory burden

Graphene-based nanocarriers for stimuli-responsive drug delivery Endogenous stimuli-responsive drug delivery pH-sensitive drug delivery Different tissues and cellular parts of the body have distinct pH levels that can operate as a stimulus in pH-sensitive drug delivery systems (Zhu and Chen, 2015)

So, a theory is that increasing biotin through supplements may increase keratin production, that could potentially lead to blocked pores

The signaling molecules that glia release are ATP (Halassa et al., 2009