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The exposure of rats cerebellar granule cells to NaCN (100 M) stimulated Ca 2+ influx into the cells (Cai and McCaslin 1992)

Accordingly, monitoring of total concentrations may be misleading since free concentrations may be substantially elevated in patients with hepatic disease whereas total concentrations may appear to be normal [see Boxed Warning, Contraindications (4), and Warnings and Precautions (5.1)]

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Conclusion Our data supports the idea of a critical involvement of glial cells in F toxicity