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Nevertheless, the aberrant activation of c-Met and downstream signaling pathways through overexpression of HGF or c-Met, gene amplification, mutational activation of c-Met, down-regulation of Met-targeted miRNA, binding to other ligands, autocrine signaling or abnormally high HGF levels initiates and drives tumorigenesis and promotes tumor growth, invasion, metastasis, and angiogenesis in HCC

It has also been associated with potential benefits for kidney disease, Alzheimer's disease, and multiple pulmonary diseases [5, 7]

The energy fluctuations of the material remained within a narrow range, indicating its thermodynamic stability at 300 K