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These chemically non-reducible all-carbon bonds, typically introduced via ring-closing metathesis (RCM) or ring-closing alkyne metathesis (RCAM), serve as effective surrogates for labile disulfide bonds, enhancing both the structural stability and metabolic resilience of peptide therapeutics ( Triazole linkages, generated through Cu(I) or Ru(I)-catalyzed azide-alkyne click cycloaddition, offer remarkable metabolic stability and synthetic versatility (White et al., 2020

22 Photodynamic therapy is used to treat many skin diseases, including actinic keratosis, basal cell carcinoma, intraepithelial lesions of the vulva and anus, and genital warts

Literature gaps and limitations In addition to the mechanism-specific gaps raised, there remain fundamental questions concerning the mitochondrial impact of GAs and the subsequent effect on the developing brain at the basic and translational levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Hamad H., Olsen B.B

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