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Chapter 22: Autoimmune diseases, Pernicious Anemia (Vitamin B12 Deficiency) PERNICIOUS ANAEMIA (PA) Definition This is megaloblastic anemia due to deficiency of vitamin B12, because of malabsorption, which is believed as an autoimmune phenomenon to gastric parietal cells and their products

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This testing ensures that each product is evaluated against clear, measurable benchmarks rather than internal assumptions

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148 The authors of these studies recommend that vitamin B12 status be assessed, both before and regularly after commencement of metformin treatment, 74,84,144,146 and for peripheral neuropathy to be assessed even in the absence of B12 deficiency