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Absolutely and often more than people expect

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Metformin use and risk of B12 deficiency increases with the dose and the duration depletion can be seen as early as 3-4 months after starting so it is important to attend for follow up blood tests and talk to your doctor

High homocysteine levels have been linked to an increased risk of heart disease, weaker bones, poor brain and kidney function, and premature death (3)

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