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Thirteen genes were identified associated with breast cancer occurrence, and that the tumor suppressor gene retinoic acid receptor beta (RAR) and the adenomatous polyposis coli (APC) promoter specific methylation interacted with PAH-DNA adducts, which affected the hormone receptor expression, and increased the risk for developing breast cancer [144]

Z., Rodrguez, M

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On one hand, the nsp12 NiRAN domain is involved in the second step to catalyse the ppA to GpppA transfer through its newly identified GTase activity

Its etio-pathogenesis and pathophysiology include roles for genetic, environmental and endocrine factors