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Studies have shown that when NNMTi is combined with a lowcalorie diet, the rate of body weight loss in obese mice is significantly faster than in either singleintervention group, with more pronounced reduction of adipose tissue and greater improvement in insulin sensitivity and hepatic metabolism

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Therefore, anti-oxidative treatments and lifestyle modifications are being investigated as potential protective strategies to restore redox balance and maintain reproductive capacity (Fig

In vivo, improved cartilage repair was achieved by articular injection of MSCs with high levels of cellular GSH and MSCs cultured under high-density conditions, as confirmed by Collagen type 2 IHC, Safranin-O staining and ODriscoll scores showing that more hyaline cartilage was formed on the defects