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There are several theories on how NRF2 is released from KEAP1 in response to cellular stress

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McCord, unpublished data).] We found that the plasma activity of PON1 was significantly higher in mdx mice supplemented with Protandim , whether for 6 weeks or 6 months

Though some studies have shown that taking antioxidants such as Vitamins E and C will prevent damage to tissues by reducing oxidant production, chronic use of these antioxidants could hinder the positive adaptive response that exercise has on the endogenous antioxidant defense system