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2019, 15:e1008289

The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness

This is sometimes called methotrexate fog, and can occur a day after receiving a dose of methotrexate (which is taken in pill form or injected once a week)

The dimer interface is formed by the interaction between loop 2 of one monomer and loop 1 of the other, stabilized by hydrogen bonds and salt bridges, resulting in a more open and flexible active site pocket compared to other GCTs