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After binding, the complex is endocytosed and degraded to heme metabolites, such as bilirubin, Fe 2+ , and carbon monoxide (CO) [109, 110]

Results and discussion Identification and validation of potent GST P1-1 inhibitors Inhibition of the reaction between CDNB and GSH in the presence of GST P1-1 has been extensively used to evaluate compounds as potential GST P1-1 inhibitors [24,29,30]