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2.2 Immune pathway crosstalk Th17 cells, the interleukin (IL)-17 producing CD4+ T helper cells, have gained significant attention due to their crucial role as important mediators of immune dysregulation, for their production of signature cytokines including IL17 and IL-17F under the induction by pathogens

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This cell-to-cell adhesion is translated into intracellular signaling pathways [37], culminating in specific alterations within the cell, at the cytoplasmatic level

138 NAMPT has an important role in the tumorigenic microenvironment in leukemia, with eNAMPT playing an important role in macrophage differentiation to the M2 phenotype and polarization in tumorigenesis-associated macrophages