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13 Moreover, most of the flavonoids, upon digestion, reach the colon unabsorbed and thus increase the abun- dance of beneficial bacteria and the production of short- chain fatty acids (FAs)

Unlike normal cells, which rely primarily on oxidative phosphorylation or glycolysis, glioblastoma cells adapt to metabolic stress by shifting between these pathways to maintain energy production and cellular integrity [156, 157]

Long-term efficacy studies indicate that many patients can achieve and maintain reasonable disease control with a continuous treatment methodology, especially when combined with folic acid supplementation to mitigate side effects

Front Oncol 13:1257767 Avancini A, Borsati A, Toniolo L, Ciurnelli C, Belluomini L, Budolfsen T et al (2025) Physical activity guidelines in oncology: a systematic review of the current recommendations

This dysfunction can lead to a variety of clinical phenotypes, particularly affecting organs with high energy demands, such as the brain and muscles