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It has been shown that baicalensis strongly prevented hepatic fibrosis by activating ERK-p53 pathways, which in turn induced G2/M cell cycle arrest and activated caspases in hepatic stellate cells (HSCs) (Pan et al., 2015)

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For example but not for limitation, if a collection of human VH CDR sequences have carboxy-terminal amino acids which are either Tyr, Val, Phe, or Asp, then the pool(s) of synthetic CDR oligonucleotide sequences are designed to allow the carboxy-terminal CDR residue to be any of these amino acids

doi: 10.1016/j.virusres.2021.198384, 60