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During niacin treatment, fasting glucose, insulin and HOMA1-IR (insulin resistance score based on blood glucose and insulin) increased in some individuals up to 1.9-fold after niacin dose of 500 mg, suggesting increased insulin resistance (Fig

Several investigational agents capable of inhibiting NLRP3 activation, such as tranilast, 354 dapansutrile (OLT1177, selective inhibitor), 354 and thiazolo-alkenyl sulfonylurea derivative 7, 355 are also being considered for COVID-CS treatment as reviewed by Freeman and Swartz

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