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it can function as a ligand that binds to TNFR1/TNFR2 and as a receptor that conducts reverse (outside-to-inside) intracellular signaling on tmTNF- expressing cells

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Although permanent infertility is rare and not extensively documented, the topic lacks large-scale, long-term studies, so some uncertainty remainsrecovery might not always reach pre-treatment levels, especially with prolonged use

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[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Knezevic M., Gojkovic S., Krezic I., Zizek H., Malekinusic D., Vrdoljak B., Knezevic T., Vranes H., Drmic D., Staroveski M., et al