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The body becomes fatigued because all of the body's energy goes into detoxing, not towards daily output

Pathogens 3 , 769790 (2014)

8,64,215 It is also known that the normal stem cells have large pools of NAD + , similar to cancer cells, 188 and the upregulation of NAMPT in these tumor cells with concomitant raise of NAD + levels de-differentiate these cancer cells to CSC like cells

doi: 10.1016/j.heliyon.2024.e24042 201 ZhengDLiuJPiaoHZhuZWeiRLiuK

Nevertheless, the selective upregulation of metabolites associated with cellular repair processes reflects an adaptive response aimed at mitigating oxidative damage