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For chromatographic metabolite separation, a Vanquish ultra-performance liquid chromatography (UPLC) system was coupled to a Q Exactive HF (QE-HF) mass spectrometer equipped with heated electrospray ionization (HESI

These proteins are the components of larger complexes that possess the ability to bind to cargo sorting receptors (e.g., sortilin), molecular motors (e.g., kinesin and dynein), and other proteins required for trafficking, such as adaptor proteins and GTPases [73]

intramuscular route: count injections given Visit 4 (week 52) Anamnesis: record lifestyle habits and use of alcohol Symptoms: record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Questionnaires: EuroQoL-5D, satisfaction and preferences Assessment of haemogram and serum vitamin B12 concentration Assessment of adverse effects Assess adherence to treatment: oral route count number of vials used

Genome-wide estimates of mutation rates and spectrum in Schizosaccharomyces pombe indicate CpG sites are highly mutagenic despite the absence of DNA methylation

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