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This productive scientific controversy has focused attention on what TB4 does reliably achieve: epicardial thickening, increased coronary capillary density, cardiomyocyte survival, and improved haemodynamic function all consistently observed across studies regardless of the differentiation debate

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High homocysteine levels exacerbate this pathology by promoting blood clotting and damaging the delicate inner lining of blood vessels, further restricting oxygen and nutrient delivery to starving tissues