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Rare : certain hypersensitivity reactions (such as hypotension, edema, anaphylactic reactions) disorientation, insomnia, psychotic irritation, paresthesia, changes of sensitivity and memory, visual disorders, tinnitus, gastrointestinal ulceration, hemorrhage, perforation, changes of taste, hematuria, proteinuria, acute renal insufficiency

Disturbances in calcium homeostasis lead to mitochondrial calcium overload, which disrupts the mitochondrial membrane potential, decreases ATP production, and ultimately triggers acinar cell death through apoptosis and necrosis (26)

For example, the appetite and craving reduction effects aren't seen once the medication is stopped

We were all there to cheer her on