In experimental and clinical studies, some drugs targeting metabolic pathways have demonstrated promising therapeutic effects, such as anti-inflammatory, anti-oxidative, and tissue repair promotion
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It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)
Biomed Pharmacother 165:115086 Zhang S et al (2023) Vitexin ameliorated diabetic nephropathy via suppressing GPX4-mediated ferroptosis
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