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Quantitative chemical proteomic profiled the in vivo toxic targets of reactive drug metabolites (Whitby et al., 2017)

These results could serve for identifying and understanding the nature of various bioactive components, with potential applications in biotechnological processes

Intestinal immune cells, such as macrophages and T cells, undergo significant changes in metabolic pathways during inflammatory states, which not only affect their functional status but also determine the nature and intensity of the immune response

Furthermore, Zhang et al

Cell viability decreased to 52.5% 2% in the group treated with 50 M for 24 h (Fig 1A) implying a half-maximal inhibitory concentration as of 50 M