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In fact, GSNO reductase-dependent oxidation of HMGSH is increased 8-fold in the presence of GSNO in vitro and more than 20-fold in crude lung and liver lysates

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Exogenously delivered miR-30e-5p phenocopied the increased atherosclerosis in EC- Slc7a11 -/- mice

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Senescent cells, through the secretion of SASP factors into their environment, influence neighboring non-senescent cells and the extracellular matrix (ECM), leading to inflammation, fibrosis, and programmed death of healthy cells, while simultaneously becoming resistant to apoptosis [34]

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