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Kovacs EM, Lejeune MP, Westerterp-Plantenga MS

Key distinctions from growth hormone include [5] : Peptide lacks growth hormone receptor binding domains (specifically binding site 2) Binding site 2 is required for receptor dimerization and activation Competitive binding assays showed AOD9604 cannot compete with hGH for receptor binding Does not function as a growth hormone receptor antagonist Glucose Metabolism Preservation Unlike full hGH, which can induce insulin resistance and hyperglycemia, AOD9604 demonstrates no adverse effects on carbohydrate metabolism

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These animals were also subjected to the same environmental conditions and treatment protocols for a chronic 28-day administration study [2]