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Not only regarded as a critical biomarker for lipid peroxidation, but 4-HNE also involves regulating Nrf2 and Nuclear factor-kappa B (NF-B) pathway (Jaganjac et al., 2020)

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doi: 10.1016/j.neuron.2015.11.023 Summary Keywords neurodevelopmental disorders, attention-deficit hyperactivity disorder, autism spectrum disorder, epilepsy, pycnogenol, gut-brain axis Citation Chen L, Li Z and Fan Y (2025) Neurodevelopmental disorders and gut-brain interactions: exploring the therapeutic potential of pycnogenol through microbial-metabolic-neural networks