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In the glycerol-3-phosphate and other pathways, the starting material is of defined stereochemistry and each of the enzymes catalysing the various steps in the process is stereoselective and has preferences for certain fatty acids (as their CoA esters) and fatty acid combinations in the partially acylated intermediates

An ushering in of this new era of therapeutics that target senescent cells offer the appealing prospect of simultaneously targeting the shared biological processes that underlie many of these diseases as well as extending lifespan and healthspan

Bell, MD, FACP, has reviewed the following frequently asked questions

Yang H, Gao S, Lu G, He J, Dong J, Zhang X, et al