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For example, mutations in the PIK3CA gene, which encodes the p110 subunit of PI3K, have been shown to promote resistance to ferroptosis in breast cancer cells [58]

irAEs led to discontinuation of NIVO in the remaining 4 patients

References Pelaia C, Calabrese C, Garofalo E et al (2021) Therapeutic role of tocilizumab in SARS-CoV-2-induced cytokine storm: rationale and current evidence

10.1016/j.stem.2010.03.020 Summary Keywords beta-Catenin, Lgr5, Axin2, supporting cells, cochlea, planar cell polarity Citation Jansson L, Kim GS and Cheng AG (2015) Making sense of Wnt signalinglinking hair cell regeneration to development