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Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB

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Potential risks include: Insulin resistance Fluid retention Carpal tunnel-like symptoms Theoretical cancer signalling concerns with chronic GH elevation Unknown long-term effects Absence of long-term harm data is not the same as proof of safety

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