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Finally, other RASopathies such as Costello syndrome and cardio-facial-cutaneous syndrome may be associated with CaLS, but this only occurs in a minority of patients and the number of lesions is usually small.3032 Caf-au-lait spots with polygonal shapes in 2 patients with LEOPARD syndrome

Premature mortality due to cardiovascular disease in hypopituitarism

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There are also various surgeries that may assist with the pain

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