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Front Plant Sci 7:153 Petrussa E, Braidot E, Zancani M, Peresson C, Bertolini A, Patui S, Vianello A (2013) Plant flavonoidsbiosynthesis, transport and involvement in stress responses

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In motor neurons, this couples to ER-stress markers (GRP78, CHOP, ATF4) and caspase-12/3 apoptotic cascades, which later subside only once cathepsin-D recoversdefining a narrow therapeutic window (Liu et al., 2015)