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For instance, it has been shown that fumarate accumulation induces persistent oxidative stress and cellular senescence in vitro and in vivo through p21 activation, a key senescence factor [97]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 263.Cvetkovic R.S., Perry C.M

347,348 Notably, miRNA-mediated gene expression control is critical for the cellular response to the environmental stresses, like starvation, hypoxia, oxidative stress, and DNA damage