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For patients where the BPC-157 pathway is no longer accessible, the substitute strategy whether an alternative peptide, conventional pharmacologic therapy, or conservative management should be characterized in advance

TGF-/Smad pathway, that may in part mediate the antiproliferative effects of DA, was found down-regulated in DA-resistant prolactinomas compared to normal human anterior pituitaries ( Novel Mechanism in Drug Resistance of Pituitary Tumors: A Role for Cytoskeleton Recently, cytoskeleton has emerged as novel player implicated in the complex mechanisms of pharmacological resistance of pituitary tumors to DA and SS

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De la Torre [7] has estimated that a treatment that delays the onset of symptoms by 5 years would reduce the number of AD patients by upwards of 50%