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Among LOX inhibitors, Zileuton (A-64077), a LOX-5 inhibitor, reduces oxidative stress by regulating ROS levels in retinal pigment epithelial (RPE) cells, offering potential for retinal disease treatment (Liu et al., 2015

Feinberg, I

Arq Esc Med Vet UFBA 19:7586 Albuquerque AF, Ribeiro JS, Kummrow F, Nogueira AJA, Montagner CC, Umbuzeiro GA (2016) Pesticides in Brazilian freshwaters: a critical review

Although the extents of decreases varied between the assays, an expected outcome due to differences in underlying technologies, the results were in agreement that a deficiency of Gpx4 occurred in symptomatic SOD1 G93A mice