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This approval represents a landmark achievement, marking the first FDA-approved pharmacological therapy specifically targeting MASH, based on evidence of fibrosis improvement without worsening of steatohepatitis [92, 93]

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Together with drugs and dietary manipulation, antioxidants are increasingly being used for the management of liver disease in dogs and cats

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Therefore, a more plausible explanation is that at pH 5.8, there are probably enough protons in the solution to shield the significant number of negative charges at the C terminus