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Under ICH conditions, iron is transported to the extracellular space through the iron export protein FPN in microglia, causing a large amount of toxic iron to enter the brain tissue ( FIGURE 4 To be specific, two-molecule Fe 3+ participates in the transport of iron by binding to one molecule of transferrin, which transports Fe 3+ to the intracellular by binding to the membrane protein transferrin receptor 1 (TFR1) on the surface of neurons to form a Tf-Fe 3+ -TFR1 complex

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10.1016/j.phymed.2020.153328 114 WenY.LiY.LiuT.HuangL.YaoL.DengD.et al (2024)