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As a vital interface with the external milieu, the intestinal barrier function plays a crucial role in safeguarding the internal homeostasis by effectively impeding the entry of harmful substances

90 In the UPS, the E3 ligase is considered an important component of the ubiquitin binding system and plays a role in substrate-specific recognition

doi: 10.1152/physrev.00030.2013 52

We are thankful for the technical services provided by the Transgenic Mouse Models Core Facility of the National Core Facility for Biopharmaceuticals, National Science and Technology Council, Taiwan, as well as the Gene Knockout Mouse Core Laboratory of the National Taiwan University Center of Genomic and Precision Medicine

50 DonatiB.LorenziniE.CiarrocchiA