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The FASEB Journal, 24(7), 2144-2151

The ensuing inflammatory cascade, marked by cytokine and chemokine release, sets the stage for platelet thrombosis, fibrinoid necrosis, bloodbrain barrier breaches, and the onset of cerebral edema [175]

While the biological mechanisms governing this processclonal expansion, mutation, and competitive selection for survival signalsare well characterized, the quantitative principles that determine the optimal evolutionary trajectory of a B-cell lineage remain an active area of theoretical investigation

Notably, the ZFPG + US treatment exhibited the most potent inhibition of metastasis, suggesting that the ZFPG + US mediated sono-metallo-immunotherapy effectively stimulated the bodys immune response, thereby impeding cancer cell metastasis within the body (Fig

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