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Among these derivatives, the most potent one is a hybrid of ISA/hydroxamic acid, ((3R,4R,6R,8R, 9R)-8-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl (4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl) benzoyl)- R -alaninate) (Derivative 11, Figure 2K), the IC 50 of which against the cancer cell lines were below 0.3 M (Mo et al., 2024)

13 For COVID-19 repurposing of an existing clinically approved drug, it is pivotal to demonstrate its antiviral, anti-inflammatory, and related effects against SARS-CoV-2 in cell-based systems in vitro

Most dogs show significant improvement in energy, stool consistency, and body condition within four to eight weeks of starting B12 supplementation alongside appropriate treatment of the underlying cause

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In contrast, microplastic exposure increased egg production, indicating variability in reproductive responses potentially influenced microplastic type, exposure duration, and reproductive stage