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One of the mutants, bzs285 , carried a mutation that creates a stop codon after amino acid 284, resulting in deletion of 52 amino acids at the C terminus of bzr1-1D protein (Fig

whereas more hydrophobicity of the compound could improve the brain permeability

Markl, D

Cellular Stress Resistance In preclinical models, MOTS-c has also been shown to help cells tolerate metabolic and oxidative stress, which is part of the basis for interest in its potential role in aging and age-related disease