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This may also be due to the anti-inflammatory effect of EMPA (Pirklbauer 2021)

Silibinin regulates tumor progression and tumorsphere formation by suppressing PD-L1 expression in non-small cell lung cancer (NSCLC) cells

Dihydroartemisinin inhibits Lewis lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway

Reduced enzymatic ROS-scavenging could, at least under homeostatic conditions, be compensated by elevated levels of NO, which we detect in SCLC cells and which may act as a ROS scavenger by reacting with superoxide to form the non-radical, slow-reacting molecule peroxynitrite (ONOO , reviewed in refs

Finally, we moved in vivo, and observed that systemic treatment with a potent GGT inhibitor decreases the growth of tumor xenografts