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Fibroblasts are central to collagen, elastin, and matrix protein production, making them a key focus in wound-repair and structural-aging research

10.1016/j.phrs.2020.105007 Pharmacol

Traditional Chinese medicine (TCM) has received extensive attention because of its advantages including minimal adverse reactions, multiple targets, and effectiveness through multiple pathways

Therefore, introducing drug development technologies, such as computer-aided drug design, high-throughput screening, systems modeling and simulation to obtain derivatives of AS-IV with increased bioavailability and conducting targeted validation or further adopting biocompatible drug carriers, such as nanoparticles, liposomes and micelles encapsulating AS-IV, may be required to achieve its efficient delivery

(1987 b )