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Description

Unlike setmelanotide, which can activate melanocortin receptors MC3R and MC1R in addition to MC4R 36 , RM-718 by design, avoids stimulating MC1R 40 and thereby avoids the common hyperpigmentation adverse event 41 that can arise when MC1R is stimulated 42

Annals of Hematology

This method may provide more direct delivery to affected muscle tissue

Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A