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Funding This research was supported by Scientific planning project of youth education in Shandong province Undergraduate Academic Project (23BSH251)

Exogenous antioxidants include vitamins, minerals, and phytochemicals that can directly scavenge free radicals or enhance the bodys own antioxidant defenses [190]

Disclosures: takayuki tokunaga: Nothing to Disclose, Kazuhiro Sugi: Nothing to Disclose, Koichi Kudo: Nothing to Disclose, Yoshinari Sakai: Nothing to Disclose, Shiho Miyase: Nothing to Disclose, Kotaro Fukubayashi: Nothing to Disclose, Masakuni Tateyama: Nothing to Disclose, Kentaro Tanaka: Nothing to Disclose, Satoshi Narahara: Nothing to Disclose, Hiroki Inada: Nothing to Disclose, Etsuko Iio: Nothing to Disclose, Yoko Yoshimaru: Nothing to Disclose, Takehisa Watanabe: Nothing to Disclose, Katsuya Nagaoka: Nothing to Disclose, Hiroko Setoyama: Nothing to Disclose, Yasuhito Tanaka: Nothing to Disclose 1824 UBE2D3 NEGATIVELY REGULATES HEPATOCARCINOGENESIS VIA SUPPRESSION OF STAT3 SIGNALING Hideharu Nagasawa 1 Takahiro Kodama 2 Kazuki Maesaka 2 Kumiko Shirai 2 Akira Doi 2 Yuki Tahata 3 Yoshinobu Saito 4 Hayato Hikita 4 Tomohide Tatsumi 3 Tetsuo Takehara 3 , 1 Department of Gastroenterology and Hepatology, Graduate Scho, 2 University of Osaka, 3 Osaka University, 4 Osaka University Graduate School of Medicine Background: Pharmacotherapy for hepatocellular carcinoma (HCC) has progressed markedly in recent years, with many drugs becoming available

Managing elevated alanine aminotransferase (ALT) levels early is crucial, as it is a key marker of liver inflammation and damage

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