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Glutathione peroxidase 4 (GPX4) is an endogenous suppressor of ferroptosis that limits peroxidation by catalyzing the glutathione (GSH)-dependent reduction of lipid hydroperoxides to lipid alcohols (LOH) and water (H 2 O) 22

The effect of orexin-A on motor and cognitive functions in a rat model of Parkinsons disease

IGF2BP3 is preferentially expressed in TNBC, where it is significantly more abundant in tumor-initiating BC cells and promotes EMT and stem-like properties [51,52,53,54]

Clinical experience from practitioners treating MCAS and histamine intolerance adds human evidence, though formal clinical trials for allergic conditions specifically are still needed

Despite the numerous challenges, advancements in technology allow for a more comprehensive analysis of energy metabolism changes in the microenvironment through integrating transcriptomics, proteomics, metabolomics, and other omics approaches