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Following a single intravenous bolus dose of 0.5 mg/kg in 10 children 4 to 8 years old, the half-life was 5.8 1.6 hours, the average clearance was 0.042 0.01 L/hr/kg, the volume of distribution during the terminal phase (V ) was 0.34 0.12 L/kg and the volume of distribution at steady state (V ss) was 0.26 0.08 L/kg

Amber Lavigne, Newcastle

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The duration of benefits also varies by delivery method

Bo Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers