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(33) analyzed the suprachiasmatic nucleus (SCN) of mice that underwent 1 week of urolithin A (20 mg/kg/day) or vehicle pre-treatment prior to dextran sulfate sodium-induced intestinal inflammation to study the effects of urolithin A on the expression of central clock genes

258 Similarly, elderly individuals exhibit weaker antibody responses upon immunization with influenza and pneumococcal vaccines, underscoring the need for enhanced immunization strategies

Studies have proposed that hypofunctioning of the NMDA receptor can induce neurodegenerative features that are similar to Alzheimers disease, and amyloidosis (abnormal deposition of beta-amyloid protein) can further deteriorate the state of NMDA receptor hypofunctioning

Oxidative stress affects numerous molecular pathways, including inhibition of the cystine/glutamate antiporter system, decreased expression of GPX4, disruption of iron homeostasis and lipid peroxidation, which is a major driver of ferroptosis activation (54)

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