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As expected by the increased striatal DA, pathways signifying activation of signalling by G-protein-coupled receptors, transmission across chemical synapses and calcium signalling were all positively enriched at 3 months in iSPN + mut (Supplementary Table 1a), whereas genes associated with metabolic pathways such as oxidative phosphorylation (OxPhos) and respiratory electron transport ATP synthesis were significantly downregulated in iSPN + mut compared to iSPN+wt at 3 months (Fig

Figure 4 - 1 shows a simplified diagram of the antigen-binding cleft of an HLA-Class I molecule, such as HLA-B27, with a 9 amino acid long bound peptide with its side chains that fit into the side pockets A to F

Cells were transfected at 24 h after seeding and subsequently treated without or with BSO at 24 h after transfection, as described above

Note that these observations are based on case reports, and do not necessarily reflect susceptibility of these demographics to toxicity (Amar 2007)

These changes create self-reinforcing pathological cycles that worsen tissue function and promote systemic insulin resistance (1517)