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AMPK is active when the cellular energy charge is low, as binding of either AMP or ADP to this kinase renders it more susceptible to stimulatory phosphorylation by its upstream kinases, liver kinase B1 (LKB1) and calmodulin-dependent protein kinase kinase 2 (CaMKK2)

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This is achieved by integrating the PD-1/PD-L1 complex small molecule inhibitor BMS-202 with a cell membrane-anchoring peptide RKC and a near-infrared-activated semiconductor polymer photosensitizer YBS (Wang et al., 2023)

Vitamin D is made when your skin is exposed to sunlight, Bostick says