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The GPX4-positive and 8-OHdG-negative group showed the worst prognosis, though there were no significant differences between the four subgroups in both OS and PFS (Fig

Key points Sperm DNA fragmentation is a major factor affecting male fertility, and can affect embryo development, embryo implantation and, ultimately, living offspring

In contrast to the MSCA1-FEA4 interaction, which depends on the active site cysteines of MSCA1 and a redox-active cysteine of FEA4 28 , the ROXY9-TGA1 interaction is independent from the CCLC signature 62

The pharmacological inhibition of ERK 1/2 can block both of these effects

[57] [56] EMA has a lower sensitivity, but its specificity is near 100%