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257 In contrast, the negative regulators of the JAK/STAT pathway, CIS, SOCS1 and SOCS3 were found frequently downregulated or lost in HCC, thus resulting in continuous activation of the pathway and HCC progression

UMAPs of all INs identified in slice culture, including postmitotically labeled GE-derived clusters

Moreover, the high complexity and heterogeneity of tumor metabolism, along with its close interaction with the TME, have collectively driven the evolution of treatment paradigms from single-agent approaches to multidimensional synergistic strategies

[DOI] [PMC free article] [PubMed] [Google Scholar] 115.Napoli I., Blusztajn J.K., Mellott T.J

A controlled trial